Opioids and affect

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Chapter 10 endnote 18, from How Emotions are Made: The Secret Life of the Brain by Lisa Feldman Barrett.
Some context is:

Opioids increase during placebo and turn down nociception, and likewise decrease during nocebo effects, earning them the moniker of “your internal medicine cabinet.”

Actually, to be more specific, opioids seem to dial down pain. (Pain is constructed when nociception is conceptualized, and includes intense affective features). They seem to be particularly important for the affective component of pain, and therefore may be relevant more generally for interoception and body-budgeting (for example, [1][2][3][4][5][6][7][8][9][10]).

Notes on the Notes

  1. Zubieta, Jon-Kar, Terence A. Ketter, Joshua A. Bueller, Yanjun Xu, Michael R. Kilbourn, Elizabeth A. Young, and Robert A. Koeppe.  2003. "Regulation of human affective responses by anterior cingulate and limbic μ-opioid neurotransmission." Archives of General Psychiatry, 60 (11):1145-1153.
  2. Pecina, Susana and Kent C. Berridge. 2005. "Hedonic Hot Spot in Nucleus Accumbens Shell: Where Do μ-Opioids Cause Increased Hedonic Impact of Sweetness?" The Journal of Neuroscience, 25 (50): 11777–11786.
  3. Mechling, Anna E., Tanzil Arefin, Hsu-Lei Lee, Thomas Bienert, Marco Reisert, Sami Ben Hamida, Emmanuel Darcq et al. 2016. "Deletion of the mu opioid receptor gene in mice reshapes the reward–aversion connectome." Proceedings of the National Academy of Sciences, doi/10.1073/pnas.1601640113.
  4. Lutz, Pierre-Eric and Brigitte L. Kieffer. 2013. "Opioid receptors: distinct roles in mood disorders." Trends in Neurosciences 36 (3): 195-206.
  5. Also see Fields, Howard L. and Elyssa B. Margolis. 2014. "Understanding opioid reward." Trends in Neurosciences, 38 (4):  217-225.
  6. Lee, Michael C., Vishvarani Wanigasekera, and Irene Tracey.  2014. "Imaging opioid analgesia in the human brain and its potential relevance for understanding opioid use in chronic pain." Neuropharmacology, 83: 123-140.
  7. Koepp, Matthias J., Alexander Hammers, A. D. Lawrence, Marie-Claude Asselin, Paul M. Grasby, and C. J. Bench. 2009. "Evidence for endogenous opioid release in the amygdala during positive emotion." NeuroImage 44 (1): 252-256.
  8. Leknes, Siri and Irene Tracey. 2008. "A common neurobiology for pain and pleasure." Nature Reviews Neuroscience, 9 (4): 314-320.
  9. Liberzon, Israel, Jon Kar Zubieta, Lorraine M. Fig, K. Luan Phan, Robert A. Koeppe, and Stephan F. Taylor. 2002. "μ-Opioid receptors and limbic responses to aversive emotional stimuli." Proceedings of the National Academy of Sciences 99 (10): 7084-7089.
  10. Castro, Daniel C. and Kent C. Berridge. 2014. "Opioid Hedonic Hotspot in Nucleus Accumbens Shell: Mu, Delta, and Kappa Maps for Enhancement of Sweetness 'Liking' and 'Wanting.'" The Journal of Neuroscience 34 (12): 4239–4250.