Chapter 12 endnote 47, from Lisa Feldman Barrett.
Some context is:
...a simple behavior like freezing is supported by multiple circuits within a distributed network that is not specific to freezing or fear.
Amygdala neurons are neither individually necessary nor collectively sufficient for "fear learning" to occur. Even a simple behavior, like freezing, is not triggered by a single circuit; instead, there appear to be multiple (degenerate) pathways within a highly interconnected set of neurons including both amygdala neurons and other neurons with the interoceptive network that control freezing. These pathways work by prediction, not by stimulus-response. And this circuitry is not specific to freezing; for example, behaviors that are interpreted as “anxiety” also rely on the same distributed circuitry.
Notes on the Notes
- Tovote, Philip, Jonathan Paul Fadok, and Andreas Lüthi. 2015. "Neuronal circuits for fear and anxiety." Nature Reviews Neuroscience 16 (6): 317-331.
- Herry, Cyril and Joshua P. Johansen. 2014. "Encoding of fear learning and memory in distributed neuronal circuits." Nature Neuroscience, 17(12):1644-1654.
- Li, Susan Shi Yuan, and Gavan P. McNally. 2014. "The conditions that promote fear learning: prediction error and Pavlovian fear conditioning." Neurobiology of Learning and Memory 108: 14-21.